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Whereas reduced-rely MBL rarely progresses to CLL, large-count MBL progresses to CLL requiring therapy at a price of 1% to two% per annum. Higher-depend MBL is distinguished from Rai 0 CLL according to whether the B-mobile depend is above or underneath five × 109/L. Whilst individuals with both of those large-rely MBL and CLL Rai phase 0 are at im